The T50 Calcification Propensity test is the first blood test ever to functionally assess your tendency to calcify. The body tightly controls the calcification process to maintain its tissues healthy. Renal patients suffer from imbalances in the calcification process. This results in the appearance of calcification in the vascular system, leading to a high risk of cardiovascular events and death. The T50 measures in a blood sample the speed of formation of very small calcified particles believed to be the drivers of calcification progression in the body.
In a clinical study of 2785 hemodialysis patients, the T50 showed* that patients having worst T50 values had a 54% increase in their risk of cardiovascular events:
This clinical study demonstrates that T50 is a unique predictor of cardiovascular events and death. In a separate study with 824 CKD patients, the T50 predicted** the actual progression of calcification over three years in advance. So far, 30+ studies with 18000+ patients have demonstrated the importance of the T50 test.

* Pasch et al., CJASN 2016, ** Bundy et al., AJKD 2019
Knowing your T50 value means knowing your calcification propensity. This is an important basis for your treating physician to personalize and optimize your therapy. Especially in advanced chronic kidney disease, the improvement of your calcification propensity, may significantly reduce the risk of cardiovascular events. By repeat measurements of T50, improvements in calcification propensity can be monitored throughout your treatment.

For further information please ask your treating physician or contact us.
What is measured in the T50?
The test measures the speed of conversion of non-toxic particles composed of calcium and phosphate (“calciprotein particle type 1”) into toxic particles (“calciprotein particle type 2”) that trigger calcification progression in arteries and other organs. The formation of these particles naturally happens in healthy and diseased individuals. In CKD however, the particles are even more toxic and thus the speed of conversion should be slowed down to improve T50 and thus the risk of cardiovascular events.

What research supports the T50 test?
Around the world, Key Opinion Leaders have evaluated the T50 test in chronic kidney disease, other medical conditions like early rupture of membranes in pregnancy and lupus, and in the general population. This work led to the publication of 30+ peer-reviewed medical publications based on testing of 18,000+ individuals, and has consistently shown improved diagnostic value over current diagnostic tests.

Where can I get my T50 test?
Please contact Calciscon at info@calciscon.com and we will provide information on how to order your T50. You may also contact Dr. Pasch directly for an appointment at his office in Bern, Switzerland, www.innere-nephro-bern.ch.

Is T50 currently covered by my insurance?
Most insurance providers do not routinely cover T50 yet. But your insurance may cover the T50 upon special request from your treating physician. Some dialysis centers offer the test as part of their routine dialysis service. Please inquire at info@calciscon.com and we will provide you information about how to ask your insurance company for special reimbursement of your T50.
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